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J. Comput. Sci. Eng. Vol.
12 (2014) 438-465 |
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QSAR Study of the Anti-cancer Activity of 38 Compounds
in Different Cancer Cell Lines Based on Neural Networks |
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Lei
Liu, Xiurui Han, Hongzong Si and Lianhua Cui
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J. Comput. Sci. Eng.
12 (2014) 438-444
！Published
June 9, 2014 |
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Abstract:Using
the MLP and the RBF, we established QSAR models for
anti-cancer activity of 38 compounds in 5 cancer cell
lines we established. These compounds are a novel class
of anticarcinogen named tricyclic 5:7:5-fused diimidazo
[4, 5-d:4¨, 5-f ][1,3] diazepines. The carcinoma cell
lines involved in this research are A549 lung cancer,
MCF-7 breast cancer, MDA-MB-231 breast cancer, OVCAR-3
ovarian cancer and PC-3 prostate cancer. Descriptors of
each molecular were calculated and some optimal were
selected for building models. Accuracies of these models
based on both methods in training groups and test groups
are over 90%, showing perfect predictive ability. These
QSAR models indicates that MLP and the RBF are great
valuable in providing guidance for designing and
synthesizing of anticancer drugs. |
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Keywords:QSAR;
Anticancer activity; RENs; MLP; RFP.
 :
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CSE-PDF |
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Impacts of PHEV Driving Types on
Electro-hydraulic Braking |
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Jinlong Liu, Xiaoyu Zhang and
Rui Huang |
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J. Comput. Sci. Eng. 12 (2014) 445-451 ！ Published June
9, 2014
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Abstract:As
automotive by-wire control technology matures, the
electro-hydraulic braking technique in Parallel Hybrid
Electric Vehicles (PHEV) can achieve the goal of ideal
braking force distribution in front and rear wheels. In
order to discuss the impacts of PHEV driving types on
recovery rate of electro-hydraulic regenerative braking,
theoretical analyses of PHEV were done on the flat and
level road. Then the braking models were established on
the platform of Matlab/Simulink and at the same time
they were simulated with certain parameters. The results
indicate that the four wheel drive (4WD) pattern has
higher efficiency than the two wheel drive (2WD) in
regenerative braking and that whether the front wheel
drive (FWD) pattern is better than rear wheel drive (RWD)
pattern in regenerative braking depends on the main
vehicle parameters and pavement friction coefficient. |
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Keywords:Electro-hydraulic
braking; Ideal braking force distribution; Regenerative
braking; Recovery rate; Driving types.
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Download (free) CSE-PDF | |
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Research on the Key Technology of
Space Laser Communication Transmission |
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Yanfeng Tang and Hongzuo
Li |
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J. Comput. Sci. Eng. 12 (2014) 452-456 ！ Published June
9, 2014
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Abstract:Because
the space laser communication has the advantages of
high speed, security and good, it is used in all
kinds of platform more and more widely. This paper
presents and analyses the key technology which needs
to be solved to realize high speed space laser
communication, and describes the way to solve the
key technology.
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Keywords:Wireless
Laser Communication; High speed; High power.
:
Download (free)
CSE-PDF |
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Study on Optical MIMO Technique of Space
Optical Communication System
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Yanfeng Tang, Hongzuo Li, Dan Xia and Ting Zhao |
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J. Comput. Sci. Eng. 12 (2014) 457-460 ！ Published June
9, 2014
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Abstract:Optical
MIMO technology of spatial optical communication system
is proposed, the characteristics are analyzed and the
system modeling is simulated. Optical MIMO technology
mainly solves the generated multipath effect of
atmospheric channel for the laser signal transmission in
space laser communication system, which enhances
anti-jamming and anti-fading capability of the system. |
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Keywords:Space
optical communication; Optical MIMO technology; Atmospheric
turbulence; Interference.
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Download (free) CSE-PDF | |
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Several Theorems Proving of Double
Integrals of Function in the Polar Coordinate |
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Peng Yang, Youfu Wu, Qing
Huang, Lingzhong Guo and Fang Yang |
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J. Comput. Sci. Eng. 12 (2014) 461-465 ！ Published June 9, 2014
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Abstract:In
the calculation of double integral of function, a simple
method is used not only simplifies the operation step,
but also is easy to understand. For some special
integration region and the integrand in the past,
usually in order to achieve the purpose of simplifying
integral functions and integration region by polar
coordinate transformation; or some integration region
and the integrand are directly represented by polar
coordinates, we have adopted polar coordinate
transformation method. In order to better calculate
double integrals of function in polar coordinate,
according to the characteristics of the polar coordinate
system, this paper under the inspiration of the
rectangular coordinate and the conclusions of this
thesis, will further promote periodicity and symmetry of
double integral of function in polar coordinates,
periodic theorem and symmetry theorem proving are given. |
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Keywords:Double
integral; Polar coordinates; Theorem; Proving.
:
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！！ from ACSS |
